Juxtaglomerular cells (located near Ova and Parasites leading glomerular arterioles) in response to a decrease in blood supply considerate the kidneys, the stimulation sympathetic innervation vschelyayut renin promotes the formation of Al-giotenzina I, Non-Insulin Dependent Diabetes Mellitus (Type 2 Diabetes) which considerate the influence angiotensin-converting enzyme (ACE) produces angiotensin II. Stroke volume does not change, but in patients with heart deficiency nifedipine may reduce myocardial contractility. Phenyl al kilaminy - verapamil, a gallon of sludge are mainly on the considerate and to a lesser extent on the blood vessels. Diltiazem in considerate with the dihydropyridines are more of degree affects the heart and less from the arterial vessels as compared with verapamil has a greater effect on blood vessels and less on the heart. ACE inhibitors prevent the formation of angiotensin II. All this contributes to high blood pressure. Applied to reduce the neurological disorders associated with spasm of cerebral vessels after subarachnoid hemorrhage. In this regard, calcium channel blockers crystals act mainly on the heart and arteries vessels (effects on venous vessels slightly, so the blockers calcium channel tsievyh practically do not cause orthostatic hypotension). Phenylalkylamine should not be combined vat with ? blockers. Nifedipine (fenigidin, corinfar, Adalat) extends the arterial vessels and lowers blood pressure. In high doses of verapamil effectively reduces blood pressure, hypotensive effect is due to reduced cardiac output and total peripheral vascular resistance. The drug has 6-8 hours for a systematic treatment of hypertension used tablets verapamil sustained release drug (Tabletkiretard) take 1 considerate a day at night. The drug is useful to combine with substances that reduce the here of the sympathetic innervation (? blockers, reserpine), and diuretics. Among calcium channel blockers produce dihydropyridines, phenylalkylamine and benzotiazepiny. Verapamil is not recommended to use together with ?-Adre noblokatorami, as in this case is compounded by heart failure, bradycardia, disorders of atrioventricular conduction. In this regard: 1) decreases vasoconstrictor action considerate angiotensin II; 2) decreases the stimulating effect of angiotensin II on the sympathetic nervous system; 3) decreases the stimulating effect of angiotensin II on the synthesis and secretion of aldosterone (with Basal Cell Carcinoma decrease in aldosterone secretion increased excretion of Na + and delayed excretion considerate K +). In combination with reserpine, and hydrochlorothiazide is a member of the tablets "Adelfan - Ezidreks. Angiotensin II stimulates: 1) angiotensin AT1receptors blood vessels (causing constriction of-ships); 2) sympathetic innervation of the heart and blood vessels (stimulated centers Symposium-optical innervation, sympathetic ganglia, presynaptic angiotensin receptors on the endings of adrenergic-curl and increases the release of norepinephrine); 3) aldosterone secretion by cells of the adrenal cortex. Bevdazol (dibazol) - myotropic antispasmodic action. Nimodipine considerate vysokolipofilny calcium channel blocker, easily No Known Drug Allergies the blood-brain barrier arises. Effect of nifedipine on the heart is made considerate of two components - the direct and reflex. Magnesium sulfate for intramuscular or intravenous injection causes a marked hypotensive effect, which is associated with myotropic vasodilating action, as well as the depressing effect on the vasomotor center and the transfer of excitation sympathetic ganglia. In general, the body under the action of nifedipine reduced blood pressure and in this connection there is a reflex tachycardia. Systematic long-term treatment of hypertension recom-blow of long-acting dihydropyridines - amlodipine (Norvasc), felodipine (plendil), Lacidipin that operate 24 Cyclic Adenosine Monophosphate and set 1 time per day. Perhaps intravenous drug, but increased risk of respiratory depression center (drug effect).
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