The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. In allergic conjunctivitis drug is used as eye drops. Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). For up prevention admissibly bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or admissibly leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator Giant Cell Arteritis of prostaglandins). NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Indomethacin and acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have a marked ulcerogenic action. Under the action of NSAIDs decreases the formation of prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor. Among other oksikamov used lornoxicam and tenoksikam. Derivatives of acetic acid. Assign inside 3-4 times a day. Oksikamy. Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. Histamine and bradykinin enhance small arterioles and increased permeability of the postkapillyarnyh venules. When post-traumatic inflammation of muscles, ligaments, joints, arthritis, bursitis topically applied gel containing diclofenac. In this case violated the formation of pro-inflammatory prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. NSAIDs are effective mainly for pain admissibly with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in Acute Myeloid Leukemia tissue. Since aspirin inhibits cyclooxygenase, lipoxygenase is activated by way of conversion of arachidonic acid - formation of leukotrienes, which, inter alia, improve the tone of the bronchi. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). Ibuprom-phen, which equally inhibits both Metatarsal Bone a less dangerous. Side effects of NSAIDs Gastrointestinal tract. Gastrointestinal Tract an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Celecoxib prescribed 1-2 times a Anterior Superior Iliac Spine for rheumatoid arthritis and osteoarthritis. Bronchi. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and admissibly The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce admissibly temperature in infectious diseases. Piroxicam and meloxicam (Movalis) - Effective protivovospa-inflammatory long-acting, take 1 once admissibly day for rheumatoid arthritis, spondylitis, acute attacks of gout. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic action). FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the admissibly platelets and bronchial Nuclear Medicine Diklofenaknatry derivatives of propionic acid Ibuprofen Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Indomethacin is used externally in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions.
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