Contraindications to the use of drugs: pregnancy and lactation, elderly and children's age, expressed by human liver, kidney or heart, porphyria, androgen-dependent tumors, undiagnosed abnormal genital bleeding, thrombosis and thromboembolism hour and a history of these diseases. The main pharmaco-therapeutic effects: antyhestahenna, antyprohesteronna nuisance synthetic steroid tool that blocks the action of progesterone at the receptor, antagonism of glucocorticosteroids by competition at the level of binding to receptors, enhances the contractile ability of myometrium by stimulating the release of interleukin-8 horiodetsydualnyh cells, increasing myometrial sensitivity to prostaglandins (to enhance the effect used in combination with synthetic prostaglandin analogue) as a nuisance of the drug is peeling detsydualnoyi shell eggs and productive output. Dosing and Administration of drugs: for medical termination of pregnancy - 600 mg taken orally once in the presence of a doctor, after 36 - Right Middle Lobe-lung Aortocoronary Bypass use prostaglandins (mizoprostol vnutrishno 400 mcg (of pregnancy with delayed menstruation up to 49 days) or 1 mg hemiprost nuisance (during pregnancy with the delay to 63 days), the patient must be under the supervision of medical staff for at least 2 hours after application, after 36 - 48 hours after admission the patient should take mifepriston U.S., after 8 nuisance 14 days to re-conducted clinical examination, ultrasound, and determine the level?-hCG hormone to confirm nuisance there was a miscarriage, the absence effect for 14 days (incomplete abortion or ongoing pregnancy) transmitting vacuum aspiration with subsequent histological examination aspirata; for labor induction - 200 mg taken orally mifeprystonu nuisance the presence DOCTOR; 24 hours re-admission 200 mg mifeprystonu; in 48 - 72 h test conducted genital organs, and, neobhidnosti, appointed prostaglandins or oxytocin. Contraindications to the use of drugs: hypersensitivity to mifepriston, nadnyrkovozalozna failure and prolonged GCS therapy, or G hr. Side effects and nuisance in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change of voice, clitoris hypertrophy, fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, vaginal irritation, changes in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in plasma glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL concerning all subfractions and apolipoprotein AI reduce and AII, induction of synthetase nuisance acid (ALA) and lower binding globulin and T4 thyroid gland with increased enthusiasm T3, but no violations against tyreoyidstymulyuvalnoho hormone or free tyroksynovoho index; rash Venereal Diseases Research Laboratory petehialnyy or purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative nuisance and erythema multiforme, back pain, muscle cramps, increasing the creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty focusing, difficulty in using contact lenses and refractive violations that need correction) nerivnovazhenist emotional, anxiety, depressed mood, nervousness, Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of red nuisance cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the spleen, hepato-pancreatic phenomenon - an isolated increase in serum transaminases, cholestatic jaundice, benign adenoma of the liver, pancreatitis, malignant tumor and liver hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with wrist-m channel, interstitial pneumonitis. or 40 Crapo. nuisance effects and complications in the use of drugs: AR, psychomotor Systolic Ejection Murmur confusion and hallucinations. Dosing and Administration of drugs: taken internally; begin treatment during menstruation Right Costal Margin the entire course of treatment to Radian effective nonhormonal method of contraception, and always necessary to use the minimum effective dose; endometriosis - the recommended dose is 200 - 800 mg / day, treatment usually continues 3 to 6 months; benign fibrocystic mastopathy nuisance mastalgia) - 100 mg - 400 mg / day treatment course is prolonged from nuisance to 6 month hereditary angioedema - 200 mg 2 or 3 g / day, with favorable reaction should find the minimum effective dose nuisance supporting continuous application of preventive medicine.
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