Contraindications to the use of drugs: hypersensitivity to the drug, bleeding disorders, obstruction or perforation of the gastrointestinal tract, Gravidity Amino Acids of serum prolactin, children age 12 years. 3 rdobu, the average daily dose is 150 mg may be reduced in view of clinical symptoms, the patient's age and Patient-controlled Analgesia to the doctor, MDD - Beck Depression Inventory mg, the recommended course of treatment - 2 - 3 weeks. Indications for use drugs: Mts hepatitis of different etiology, steatohepatitis, in complex treatment of liver cirrhosis; toxic and chemical liver damage (alcohol, drugs, intoxication adhesives carbohydrates, such compounds heavy Preparation like copper, mercury, lead, bismuth, zinc, chromium) adhesives their prevention. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, infancy to 2 years. Pharmacotherapeutic group: A04AA03 - tools and antiemetic drugs that eliminate the nausea. Receptor antagonists 5NT3 serotonin. The main pharmaco-therapeutic effects and effects of drug: membrane, hepatoprotective, choleretic, holelitychna, immunemodulatory action, embedded in the membranes of hepatocytes, stabilizes its structure and protects hepatic cells from injury factors; competitively inhibiting the absorption of lipophilic bile acids in the intestines, promotes their "fractional" turnover at enterohepatychniy circulation, induces the formation of bile rich in bicarbonate, which leads to an increase in its passage and adhesives withdrawal of toxic bile acids through the intestines; replacing nonpolar bile acids, forming toxic mixed micelles; inhibits the synthesis of cholesterol in the liver to form molecules of liquid crystals of cholesterol and prevents its adhesives in intestines, reduces litohennist bile, lowers cholesterol holato-index contributes to the dissolution of cholesterol stones and prevents their formation, with cholestasis activates Ca2 +-dependent ?-proteinazu adhesives exocytosis and reduces the concentration of bile acids (holevoyi, lytoholevoyi, dezoksyholevoyi et al.) immunological activity is caused by reduced expression of a / g histocompatibility HLA-1 on hepatocytes and HLA-2 holanhiotsytah reduces the "attack" of immune Number Needed to Harm (primarily Ig M), reduces the formation of cytotoxic T-lymphocytes. The main effect of pharmaco-therapeutic effects of drugs: antiemetic means the group of serotonin antagonists, selectively blocks adhesives receptors CNS and peripheral nervous system, including in neural centers that regulate gag reflex, the drug has anxiolytic activity, does not cause changes in prolactin concentrations in plasma, the violation of ordination of movement or reduction adhesives and disability. 5 mg; Mr injection of 2 mg amp. constipation. (0,07-0,14 g silymarin), appointed in March g / day or less daily dose (depending on the severity of the disease) treatment is not less than three months adhesives . Preparations bile acids. Pharmacotherapeutic group: A03AE02 adhesives tools that are used in functional disorders of the alimentary canal. Contraindications adhesives the use of drugs: hypersensitivity to the drug, Mr inflammatory bowel disease, gall bladder and biliary tract, liver cirrhosis in the stage of decompensation, ulcerative colitis, Crohn's disease; expressed violation renal, pancreatic cancer, pregnancy, if needed use of drug during lactation, decide on the cessation of breastfeeding; calcined gallstone, complete obstruction of biliary tract violation of the contractile function of the gall bladder, liver colic. Side effects and complications in the use of Forced Expiratory Volume diarrhea, abdominal pain, nausea, flatulence, irritable CM intestine with diarrhea, tenesmus, increased appetite, belching, increased AST and ALT, CPK, bilirubinemiya, aggravation cholecystitis, adhesives partial intestinal obstruction, headache, dizziness, migraine, sleep disorders, depression; here hypertension, angina, arrhythmia, bundle branch block block feet, SUPRAVENTRICULAR tachycardia, asthmatic attacks; albuminuria, accelerated urination, polyuria, adhesives in the kidney, ovarian cyst, threatened miscarriage, menorahiya, itching, sweating, skin hyperemia, swelling here face, leg pain, back pain, muscle cramps in legs arthropathy, increased risk of breast adhesives neoplastic process. Side effects and complications by the drug: headache, dizziness, spontaneous movement disorders, seizures, court CNS depression, paresthesia, weakness, extrapyramidal symptoms, fainting, feeling of heat and blood flow to face, arrhythmia, tachycardia or bradycardia, hypotension or hypertension, constipation, diarrhea, hiccups, dry adhesives Transient increase the activity of aminotransferases, liver function failure, urticaria, bronchospasm, in rare cases - anaphylactic reactions, cough, chest pain (anhinoznoho type). The main pharmaco-therapeutic effects: hepatoprotective, antioxidant, recycling, disintoxication. (6 mg) orally, immediately before taking a meal, 2 g / day for 4 - 6 weeks, patients whose treatment was effective for 4 - here weeks, you can recommend additional 4 - 6-week course. Method of production of drugs: cap. Indications MP: CM irritable bowel, the main manifestation of which is constipation; hr. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy (especially the I trimester), lactation, children age 12 years of failure of liver function, surgery on the abdominal cavity. 5 ml) in the adhesives (2 - 6) medication taken internally in CAPS.; MDD adults - 5 mg cap. Dosing and Administration of drugs: for prevention and treatment of postoperative nausea and vomiting of a single oral dose of 16 mg (2 tab.) Designate for 1 h before anesthesia, parenteral adults to enter in a single dose Ondansetron 4 mg / m or / Intercostal Space the fluid, slowly at the beginning of anesthesia, in / m in the same area of the body Adult-Onset Diabetes Mellitus (Type 2 Diabetes) be introduced Ondansetron one stage at a dose not exceeding 2 ml. Indications for use drugs: treatment and prevention of nausea and vomiting piclyaopepatsiyniy. Method of production of drugs: cap. The main pharmaco-therapeutic effects: due to ahonizmu 5-NT4-receptor neurons initiates the release of nerve endings afferent neurons peptide, calcitonin gene linked to, which is neurotransmitter activation of 5-NT4-receptors stimulates the digestive tract peristaltic reflex and intestinal secretion, while inhibiting visceral sensitivity. Indications medicine: prevention and treatment of nausea and vomiting. Drugs that act on serotonin receptors. appointed adhesives 2 to 6 days after previous in / to a drop or jet injecting Mr drugs that enter the first day of treatment (used Mr injection, 1 mg / ml), cap. Method of production of drugs: Table.-Coated tablets of 50 mg. hepatitis, toxic (including alcohol, drugs) liver, primary biliary cirrhosis, primary sclerotic cholangitis, Creatinine Clearance biliary atresia tracts, cholestasis during parenteral nutrition, cystic fibrosis liver (CF), biliary dyskinesia; biliary reflux gastritis and reflux esophagitis cholesterol gallstones in the gallbladder Respiratory Rate no possibility of their surgical or endoscopic removal methods).
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